Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms

Thio, T.H.G. and Soroori, S. and Ibrahim, F. and Al-Faqheri, W. and Soin, N. and Kulinsky, L. and Madou, M. (2013) Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms. Medical and Biological Engineering and Computing, 51 (5). pp. 525-535. ISSN 0140-0118, DOI https://doi.org/10.1007/s11517-012-1020-7.

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Abstract

This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure. © 2013 International Federation for Medical and Biological Engineering.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Thio, Tzer Hwai Gilbert Soroori, Salar Ibrahim, Fatimah Al-Faqheri, Wisam Soin, Norhayati Kulinsky, Lawrence Madou, Marc eng 1 R01 AI089541-01/AI/NIAID NIH HHS/ R01 AI089541/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/01/08 06:00 Med Biol Eng Comput. 2013 May;51(5):525-35. doi: 10.1007/s11517-012-1020-7. Epub 2013 Jan 6.
Uncontrolled Keywords:	Burst frequency equation, Centrifugal, Compact disc (CD), Microfluidics, Passive valve, Burst frequency, Centrifugal microfluidic platform, Hydraulic diameter, Modified equation, Multi-stage models, Passive valves, Theoretical development, Aspect ratio, Centrifugation, Compact disks, algorithm, article, compact disk, electronics, equipment, equipment design, hydrodynamics, theoretical model, Algorithms, Miniaturization, Models, Theoretical
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Engineering
Depositing User:	Mr Jenal S
Date Deposited:	07 Apr 2014 03:07
Last Modified:	01 Nov 2017 06:01
URI:	http://eprints.um.edu.my/id/eprint/9349

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