Novel liquid equilibrium valving on centrifugal microfluidic CD platform

Al-Faqheri, W. and Ibrahim, F. and Thio, T.H.G. and Arof, Hamzah and Madou, M. (2013) Novel liquid equilibrium valving on centrifugal microfluidic CD platform. In: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, 2013, Osaka.

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One of the main challenges faced by researchers in the field of microfluidic compact disc (CD) platforms is the control of liquid movement and sequencing during spinning. This paper presents a novel microfluidic valve based on the principle of liquid equilibrium on a rotating CD. The proposed liquid equilibrium valve operates by balancing the pressure produced by the liquids in a source and a venting chamber during spinning. The valve does not require external forces or triggers, and is able to regulate burst frequencies with high accuracy. In this work, we demonstrate that the burst frequency can be significantly raised by making just a small adjustment of the liquid height in the vent chamber. Finally, the proposed valve ng method can be used separately or combined with other valving methods in advance microfluidic processes. © 2013 IEEE.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Conference code: 100170 Export Date: 29 January 2014 Source: Scopus Art. No.: 6610797 doi: 10.1109/EMBC.2013.6610797 Language of Original Document: English Correspondence Address: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia References: Madou, M., Zoval, J., Jia, G., Kido, H., Kim, J., Kim, N., Lab on a CD (2006) Annual Review of Biomedical Engineering, 8, pp. 601-628. , , 8; Zoval, J.V., Madou, M.J., Centrifuge-based fluidic platforms (2004) Proceedings of the IEEE, 92, pp. 140-153; Duc�ee, J., Haeberle, S., Lutz, S., Pausch, S., Stetten, F.V., Zengerle, R., The centrifugal microfluidic bio-disk platform (2007) Journal of Micromechanics and Microengineering, 17, pp. S103-S115; Ibrahim, F., Nozari, A.A., Jahanshahi, P., Soin, N., Rahman, N.A., Dawal, S.Z.M., Kahar, M.K.B.A., Madou, M., Analysis and experiment of centrifugal force for microfluidic ELISA CD platform (2010) Proceedings of the IEEE Conference on Biomedical Engineering and Sciences (IECBES), pp. 466-470. , Kuala Lumpur, DOI 10.1109/IECBES.2010.5742282; Strohmeier, O., Emperle, A., Roth, G., Mark, D., Zengerle, R., Stetten, F.V., Centrifugal gas-phase transition magnetophoresis (GTM)- A generic method for automation of magnetic bead based assays on the centrifugal microfluidic platform and application to DNA purification (2013) Lab on a Chip; Amasia, M., Cozzens, M., Madou, M.J., Centrifugal microfluidic platform for rapid PCR amplification using integrated thermoelectric heating and ice-valving (2012) Sensors and Actuators, B: Chemical, 161 (1), pp. 1191-1197; Lee, B.S., Lee, J.N., Park, J.M., Lee, J.G., Kim, S., Cho, Y.K., Ko, C., A fully automated immunoassay from whole blood on a disc (2009) Lab Chip, 9, pp. 1548-1555; Thio, T.H.G., Soroori, S., Ibrahim, F., Al-Faqheri, W., Soin, N., Kulinsky, L., Madou, M., Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms (2013) Medical & Biological Engineering & Computing, , DOI 10.1007/s11517-012-1020-7; Thio, T., Nozari, A.A., Soin, N., Kahar, M.K.B.A., Dawal, S.Z.M., Samra, K.A., Madou, M., Ibrahim, F., Hybrid capillary-flap valve for vapor control in point-of-care microfluidic cd (2011) 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, 35, pp. 578-581. , N. Osman, W. Abas, A. Wahab, and H.-N. Ting, Eds. ed: Springer Berlin Heidelberg; Abi-Samra, K., Hanson, R., Madou, M., Gorkin III, R.A., Infrared controlled waxes for liquid handling and storage on a cd-microfluidic platform (2011) Lab Chip, 11, pp. 723-726
Uncontrolled Keywords: Burst frequency, Centrifugal microfluidics, External force, Liquid equilibria, Liquid height, Microfluidic process, Microfluidic valves, Microfluidics, Liquids
Subjects: T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Mr Jenal S
Date Deposited: 24 Mar 2014 03:33
Last Modified: 23 Oct 2018 01:33

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