Immunomodulation and regenerative capacity of MSCs for long-COVID

Loke, Xin Ya and Imran, Siti A. M. and Tye, Gee Jun and Wan Kamarul Zaman, Wan Safwani and Nordin, Fazlina (2021) Immunomodulation and regenerative capacity of MSCs for long-COVID. International Journal of Molecular Sciences, 22 (22). ISSN 1422-0067, DOI

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The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments.

Item Type: Article
Funders: Medical Faculty of Universiti Kebangsaan Malaysia (FF-2020-327), Medical Faculty of Universiti Kebangsaan Malaysia (FPR-1)
Uncontrolled Keywords: MSCs; Long-COVID; Immunomodulation; Regeneration
Subjects: R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Ms Zaharah Ramly
Date Deposited: 14 Jun 2022 03:09
Last Modified: 14 Jun 2022 03:09

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