Loke, Xin Ya and Imran, Siti A. M. and Tye, Gee Jun and Wan Kamarul Zaman, Wan Safwani and Nordin, Fazlina (2021) Immunomodulation and regenerative capacity of MSCs for long-COVID. International Journal of Molecular Sciences, 22 (22). ISSN 1422-0067, DOI https://doi.org/10.3390/ijms222212421.
Full text not available from this repository.Abstract
The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments.
| Item Type: | Article |
|---|---|
| Funders: | Medical Faculty of Universiti Kebangsaan Malaysia (FF-2020-327), Medical Faculty of Universiti Kebangsaan Malaysia (FPR-1) |
| Uncontrolled Keywords: | MSCs; Long-COVID; Immunomodulation; Regeneration |
| Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 Jun 2022 03:09 |
| Last Modified: | 14 Jun 2022 03:09 |
| URI: | http://eprints.um.edu.my/id/eprint/27916 |
Actions (login required)
 |
View Item |
