Multi-level 3D implementation of thermo-pneumatic pumping on centrifugal microfluidic CD platforms

Thio, T.H.G. and Ibrahim, F. and Al-Faqheri, W. and Soin, N. and Abdul Kahar, M.K.B. and Madou, M. (2013) Multi-level 3D implementation of thermo-pneumatic pumping on centrifugal microfluidic CD platforms. In: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, 2013, Osaka.

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Abstract

Thermo-pneumatic (TP) pumping is a method employing the principle of expanding heated air to transfer fluids back towards the CD center on the centrifugal microfluidic CD platform. While the TP features are easy to fabricate as no moving parts are involved, it consumes extra real estate on the CD, and because heating is involved, it introduces unnecessary heating to the fluids on the CD. To overcome these limitations, we introduce a multi-level 3D approach and implement forced convection heating. In a multi-level 3D CD, the TP features are relocated to a separate top level, while the microfluidic process remains on a lower bottom level. This allows for heat shielding of the fluids in the microfluidic process level, and also improve usage of space on the CD. To aid in future implementations of TP pumping on a multi-level 3D CD, studies on the effect of heat source setting, and the effect of positioning the TP feature (it distance from the CD center) on CD surface heating are also presented. In this work, we successfully demonstrate a multi-level 3D approach to implement TP pumping on the microfluidic CD platform. © 2013 IEEE.

Item Type:	Conference or Workshop Item (Paper)
Funders:	UNSPECIFIED
Additional Information:	Conference code: 100170 Export Date: 29 January 2014 Source: Scopus Art. No.: 6610798 doi: 10.1109/EMBC.2013.6610798 Language of Original Document: English Correspondence Address: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia References: Madou, M., Zoval, J., Jia, G., Kido, H., Kim, J., Kim, N., Lab on a CD (2006) Annual Review of Biomedical Engineering, 8, pp. 601-628; Zoval, J.V., Madou, M.J., Centrifuge-based fluidic platforms (2004) Proceedings of the IEEE, 92, pp. 140-153; Ducrée, J., Haeberle, S., Lutz, S., Pausch, S., Stetten, F.V., Zengerle, R., The centrifugal microfluidic bio-disk platform (2007) Journal of Micromechanics and Microengineering, 17, pp. S103-S115; Lee, B.S., Lee, J.N., Park, J.M., Lee, J.G., Kim, S., Cho, Y.K., Ko, C., A fully automated immunoassay from whole blood on a disc (2009) Lab on a Chip, 9, pp. 1548-1555; Ibrahim, F., Nozari, A.A., Jahanshahi, P., Soin, N., Rahman, N.A., Dawal, S.Z.M., Kahar, M.K.B.A., Madou, M., Analysis and experiment of centrifugal force for microfluidic ELISA CD platform (2010) Proceedings of the IEEE Conference on Biomedical Engineering and Sciences (IECBES), pp. 466-470. , Kuala Lumpur, DOI 10.1109/IECBES.2010.5742282; Yusoff, N.A., Soin, N., Ibrahim, F., Lab-on-a-disk as a potential microfluidic platform for dengue NS1-ELISA (2009) Proceedings of IEEE Symposium on Industrial Electronics & Applications (ISIEA) Kuala Lumpur, pp. 946-950. , DOI 10.1109/ISIEA.2009.5356330; Kido, H., Micic, M., Smith, D., Zoval, J., Norton, J., Madou, M., A novel, compact disk-like centrifugal microfluidics system for cell lysis and sample homogenization (2007) Colloids and Surfaces B: Biointerfaces, 58, pp. 44-51; Burger, J., Gross, A., Mark, D., Von Stetten, F., Zengerle, R., Roth, G., Ir thermocycler for centrifugal microfluidic platform with direct on-disk wireless temperature measurement system (2011) Proceedings of the 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, pp. 2867-2870. , Beijing, China; Amasia, M., Cozzens, M., Madou, M.J., Centrifugal microfluidic platform for rapid PCR amplification using integrated thermoelectric heating and ice-valving (2012) Sensors and Actuators, B: Chemical, 161, pp. 1191-1197; Abi-Samra, K., Clime, L., Kong, L., Gorkin III, R., Kim, T.H., Cho, Y.K., Madou, M., Thermo-pneumatic pumping in centrifugal microfluidic platforms (2011) Microfluidics and Nanofluidics, 11, pp. 643-652; Handique, K., Burke, D.T., Mastrangelo, C.H., Burns, M.A., Onchip thermopneumatic pressure for discrete drop pumping (2001) Analytical Chemistry, 73, pp. 1831-1838; Ha, S.M., Cho, W., Ahn, Y., Disposable thermo-pneumatic micropump for bio lab-on-a-chip application (2009) Microelectronic Engineering, 86, pp. 1337-1339; Thio, T.H.G., Soroori, S., Ibrahim, F., Al-Faqheri, W., Soin, N., Kulinsky, L., Madou, M., Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms (2013) Medical & Biological Engineering & Computing, , DOI 10.1007/s11517-012-1020-7
Uncontrolled Keywords:	Centrifugal microfluidics, Heat sources, Heated air, Microfluidic process, Moving parts, Real estate, Surface heating, Centrifugation, Fluidic devices, Heating, Microfluidics, Pneumatics, Pumps, Three dimensional
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Engineering
Depositing User:	Mr Jenal S
Date Deposited:	24 Mar 2014 03:32
Last Modified:	01 Nov 2017 05:38
URI:	http://eprints.um.edu.my/id/eprint/9312

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