Hybrid capillary-flap valve for vapor control in point-of-care microfluidic CD

Thio, T. and Nozari, A.A. and Soin, N. and Kahar, M.K.B.A. and Md Dawal, Siti Zawiah and Samra, K.A. and Madou, M. and Ibrahim, F. (2011) Hybrid capillary-flap valve for vapor control in point-of-care microfluidic CD. In: 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011, 2011, Kuala Lumpur.

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Abstract

Microfluidics allows for the miniaturization of laboratory processes onto a compact disc (CD). A microfluidic CD provides a cost-effective, portable and automated diagnostic platform without the use of bulky equipment and complex machinery. This reduction in the cost, footprint, and user input allows for the development of tools suitable for point-of-care applications. One of the criteria for point-of-care applications is the ability to have long storage life. During storage, the reagents/chemicals in typical microfluidic CDs might evaporate and mix together before actual usage, compromising on the integrity of the result. To complement the use of capillary valves, this paper presents various available valves for vapor control, and introduces a hybrid capillary-flap valve for use in microfluidic CDs for point-of-care applications. © 2011 Springer-Verlag.

Item Type:	Conference or Workshop Item (Paper)
Funders:	UNSPECIFIED
Additional Information:	Conference code: 85436 Export Date: 29 January 2014 Source: Scopus doi: 10.1007/978-3-642-21729-6₁₄₄ Language of Original Document: English Correspondence Address: Thio, T.; Dept. of Biomedical Engineering, Faculty of Engineering, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia; email: gilbertthio@hotmail.com References: Madou, M., Zoval, J., Jia, G., (2006) Lab on A CD, , DOI: 10.1146/annurev.bioeng.8.061505.095758; Lee, B.S., Lee, J., Park, J., A fully automated immunoassay from whole blood on a disc (2009) Movie, pp. 1548-1555. , DOI: 10.1039/b820321k; Ducr, J., Haeberle, S., Lutz, S., (2007) The Centrifugal Microfluidic Bio-Disk Platform 103, , DOI: 10.1088/0960-1317/17/7/S07; Gorkin, R., Park, J., Siegrist, J., Centrifugal microfluidics for biomedical applications (2010) Lab on A Chip, , 1017581773; Lai, S., Wang, S., Luo, J., Design of a Compact Disk-like Microfluidic Platform for Enzyme-Linked Immunosorbent Assay (2004) Anal. Chem., 76, pp. 1832-1837; Gli, A., Delattre, C., Modeling and fabrication of capillary stop valves for planar microfluidic systems (2006) Sensors and Actuators, 131, pp. 601-608. , DOI: 10.1016/j.sna.2005.12.011; Nolte, D.D., (2009) Invited Review Article: Review of Centrifugal Microfluidic and Bio-optical Disks, pp. 1-22. , DOI: 10.1063/1.3236681; Siegrist, J., Gorkin, R., Bastien, M., Validation of a centrifugal microfluidic sample lysis and homogenization platform for nucleic acid extraction with clinical samples (2010) Society, pp. 363-371. , DOI: 10.1039/b913219h; Siegrist, J., Gorkin, R., Clime, L., Serial siphon valving for centrifugal microfluidic platforms (2010) Microfluidics and Nanofluidics, pp. 55-63. , DOI: 10.1007/s10404-009-0523-5; Microfluidics, C., Zengerle, R., Microfluidics 2: Microfluidic Platforms for Lab-on-a-Chip Applications 4 (2008) Centrifugal Microfluidics Technology, pp. 1-71; Chang, H.L., On-demand double emulsification utilizing pneumatically actuated, selectively surface-modified PDMS microdevices (2010) Microfluidics and Nanofluidics, , DOI: 10.1007/s10404-010-0629-9; Weaver, J.A., Melin, J., Stark, D., Pressure-gain valves (2010) Nature Physics, 6, pp. 218-223. , Nature Publishing Group DOI: 10.1038/nphys1513; Mahalanabis, M., Do, J., Klapperich, C.M., An integrated disposable device for DNA extraction and helicase dependent amplification (2010) Biomedical Microdevices, pp. 353-359. , DOI: 10.1007/s10544-009-9391-8; Zhou, P., Young, L., Chen, Z., Weak solvent based chip lamination and characterization of on-chip valve and pump (2010) Biomedical Microdevices, , DOI: 10.1007/s10544-010-9436-z; Oraes, C.H., Yss, K.R., Risson, E.M., (2010) An Undergraduate Lab (On-a-Chip): Probing Single Cell Mechanics on A Microfluidic Platform, , DOI: 10.1007/s12195-010-0124-0; Mu, J., Wang, M., Yin, X., Sensors and Actuators B: Chemical A simple subatmospheric pressure device to drive reagents through microchannels for solution-phase synthesis in a parallel fashion (2010) Sensors & Actuators: B. Chemical, 146 (1), pp. 410-413. , Elsevier B.V. doi: 10.1016/j.snb.2010.01.050; Markov, D.A., Manuel, S., Shor, L.M., Tape underlayment rotary-node (TURN) valves for simple on-chip microfluidic flow control (2010) Biomedical Microdevices, pp. 135-144. , DOI: 10.1007/s10544-009-9368-7; Garcia-cordero, J.L., Kurzbuch, D., Benito-lopez, F., Optically addressable single-use microfluidic valves by laser printer lithography (2010) Lab on A Chip M, , DOI: 10.1039/c004980h; Chen, J.M., Huang, P.-C., Lin, M.-G., Analysis and experiment of capillary valves for microfluidics on a rotating disk (2008) Microfluidics and Nanofluidics, 4 (5), pp. 427-437. , DOI 10.1007/s10404-007-0196-x
Uncontrolled Keywords:	BioMEMS, Capillary valve, flap valve, microfluidic compact disc, point-of-care, Automated diagnostics, CdS, Compact disc, Complex machinery, Laboratory process, Point of care, Storage life, User input, Vapor control, Biomedical engineering, Compact disks, Machinery, Vapors, Microfluidics
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Engineering
Depositing User:	Mr Jenal S
Date Deposited:	26 Mar 2014 02:23
Last Modified:	27 Feb 2019 01:20
URI:	http://eprints.um.edu.my/id/eprint/9298

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