Effect of temperature on the characteristics of beta-tricalcium phosphate for use as bone substitute material

Bang, L.T. and Ramesh, S. and Long, Bui Duc and Son, Nguyen Anh and Trung, Tran Bao and Sivakumar, S. (2022) Effect of temperature on the characteristics of beta-tricalcium phosphate for use as bone substitute material. Journal of Engineering Science and Technology, 17 (2). pp. 1577-1588. ISSN 1823-4690,

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Beta tricalcium phosphate (β-TCP) has received great attention mainly because of its excellent biodegradability. However, synthesis of single phase β-TCP with controlled properties without affecting the biocompatibility of the ceramic is a challenge. The aim of this research was to synthesize bioresrobable and osteoconductive β-TCP for use as a bone substitute material and to evaluate the mechanical properties of the ceramic. In this work, a two-step heat treatment process was adopted. Initially, the material was heat-treated at 700 °C, and subsequently sintered at different temperatures of 1000, 1100 and 1200 °C. It was revealed that the stability of the β-TCP phase was disrupted when sintered at 1200 oC with some formation of a-TCP phase. The diametral tensile strength of phasepure β-TCP sample was found to be about 4.06 MPa and was found to decline in the presence of α-TCP phase. Biological cell study showed that the β-TCP sample is excellent as a substrate for cell attachment, proliferation, differentiation, and mineralization, thus demonstrating excellent biocompatibility. This study showed that the β-TCP exhibited great potential for use as bone substitute materials. © School of Engineering, Taylor's University.

Item Type: Article
Funders: Hanoi University of Science and Technology (HUST) [Grant No: T2018-TT-206]
Uncontrolled Keywords: Bone substitute; Calcium phosphate; Direct sintering; Tricalcium phosphate
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering > Department of Mechanical Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Nov 2023 03:00
Last Modified: 17 Nov 2023 03:00
URI: http://eprints.um.edu.my/id/eprint/43306

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