EEG Source Imaging (ESI) utility in clinical practice

Khosropanah, Pegah and Ho, Eric Tatt-Wei and Lim, Kheng Seang and Fong, Si Lei and Le, Minh-An Thuy and Narayanan, Vairavan (2020) EEG Source Imaging (ESI) utility in clinical practice. Biomedical Engineering / Biomedizinische Technik, 65 (6). pp. 673-682. ISSN 0013-5585, DOI

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Epilepsy surgery is an important treatment modality for medically refractory focal epilepsy. The outcome of surgery usually depends on the localization accuracy of the epileptogenic zone (EZ) during pre-surgical evaluation. Good localization can be achieved with various electrophysiological and neuroimaging approaches. However, each approach has its own merits and limitations. Electroencephalography (EEG) Source Imaging (ESI) is an emergingmodel-based computational technique to localize cortical sources of electrical activity within the brain volume, three-dimensionally. ESI based pre-surgical evaluation gives an overall clinical yield of 73-91%, depending on choice of head model, inverse solution and EEG electrode density. It is a cost effective, non-invasive method which provides valuable additional information in presurgical evaluation due to its high localizing value specifically inMRI-negative cases, extra or basal temporal lobe epilepsy, multifocal lesions such as tuberous sclerosis or cases with multiple hypotheses. Unfortunately, less than 1% of surgical centers in developing countries use this method as a part of pre-surgical evaluation. This review promotes ESI as a useful clinical tool especially for patients with lesion-negative MRI to determine EZ cost-effectively with high accuracy under the optimized conditions.

Item Type: Article
Funders: Universiti Malaya [Grant No: RP052C-17HTM]
Uncontrolled Keywords: EEG source imaging; Epilepsy; Epilepsy surgery; Epileptogenic zone
Subjects: R Medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RD Surgery
Divisions: Faculty of Medicine
Faculty of Medicine > Medicine Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 29 Nov 2023 05:48
Last Modified: 29 Nov 2023 05:48

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