Comparative analysis of pediatric COVID-19 infection in Southeast Asia, South Asia, Japan, and China

Wong, Judith Ju Ming and Abbas, Qalab and Chuah, Soo Lin and Malisie, Ririe Fachrina and Pon, Kah Min and Katsuta, Tomohiro and Dang, Hongxing and Lee, Pei Chuen and Jayashree, Muralidharan and Sultana, Rehena and Maha, Quratulain and Gan, Chin Seng and Shimizu, Naoki and Xu, Feng and Tang, Swee Fong and Shi, Luming and Lee, Jan Hau and Thoon, Koh Cheng and Yung, Chee Fu and Grp, PACCMAN Res (2021) Comparative analysis of pediatric COVID-19 infection in Southeast Asia, South Asia, Japan, and China. American Journal of Tropical Medicine and Hygiene, 105 (2). pp. 413-420. ISSN 0002-9637, DOI

Full text not available from this repository.


There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Laboratory-confirmed COVID-19 cases were included in this registry. The primary outcome was severity of COVID-19 infection as defined by the World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical and laboratory features, and outcomes of children with COVID-19 are described. Univariate and multivariable logistic regression models were used to identify risk factors for severe/critical disease. A total of 260 COVID-19 cases from eight hospitals across seven countries (China, Japan, Singapore, Malaysia, Indonesia, India, and Pakistan) were included. The common clinical manifestations were similar across countries: fever (64%), cough (39%), and coryza (23%). Approximately 40% of children were asymptomatic, and overall mortality was 2.3%, with all deaths reported from India and Pakistan. Using the multivariable model, the infant age group, presence of comorbidities, and cough on presentation were associated with severe/critical COVID-19. This epidemiological study of pediatric COVID-19 infection demonstrated similar clinical presentations of COVID-19 in children across Asia. Risk factors for severe disease in children were age younger than 12 months, presence of comorbidities, and cough at presentation. Further studies are needed to determine whether differences in mortality are the result of genetic factors, cultural practices, or environmental exposures.

Item Type: Article
Funders: Sing Health Duke-NUS Global Health Institute Pilot Research Grant [Duke-NUS/SDGHI_RGA[Khoo]/2020/0006], Singapore Clinical Research Institute, SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant [AM/COV001/2020]
Uncontrolled Keywords: Multisystem Inflammatory Syndrome; SARS-Cov-2 Infection; Transmission; Epidemic; Outbreak; Children
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
T Technology > T Technology (General)
Divisions: Faculty of Medicine > Paediatrics Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 01 Aug 2022 00:21
Last Modified: 01 Aug 2022 00:21

Actions (login required)

View Item View Item