Fluid-structure interaction (FSI) modeling of bone marrow through trabecular bone structure under compression

Rabiatul, A. A. R. and Fatihhi, S. J. and Md Saad, Amir Putra and Zakaria, Zulfadzli and Harun, M. N. and Kadir, M. R. A. and ochsner, Andreas and Tunku Zainol Abidin, Tunku Kamarul Zaman and Syahrom, Ardiyansyah (2021) Fluid-structure interaction (FSI) modeling of bone marrow through trabecular bone structure under compression. Biomechanics and Modeling in Mechanobiology, 20 (3). pp. 957-968. ISSN 1617-7940, DOI https://doi.org/10.1007/s10237-021-01423-x.

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The present study has sought to investigate the fluid characteristic and mechanical properties of trabecular bone using fluid-structure interaction (FSI) approach under different trabecular bone orientations. This method imposed on trabecular bone structure at both longitudinal and transverse orientations to identify effects on shear stress, permeability, stiffness and stress regarded to the trabeculae. Sixteen FSI models were performed on different range trabecular cubes of 27 mm(3) with eight models developed for each longitudinal and transverse direction. Results show that there was a moderate correlation between permeability and porosity, and surface area in the longitudinal and transverse orientations. For the longitudinal orientation, the permeability values varied between 3.66 x 10(-8) and 1.9 x 10(-7) and the sheer stress values varied between 0.05 and 1.8 Pa, whilst for the transverse orientation, the permeability values varied between 5.95 x 10(-10) and 1.78 x 10(-8) and the shear stress values varied between 0.04 and 3.1 Pa. Here, transverse orientation limits the fluid flow from passing through the trabeculae due to high shear stress disturbance generated within the trabecular bone region. Compared to physiological loading direction (longitudinal orientation), permeability is higher within the range known to trigger a response in bone cells. Additionally, shear stresses also increase with bone surface area. This study suggests the shear stress within bone marrow in real trabecular architecture could provide the mechanical signal to marrow cells that leads to bone anabolism and can depend on trabecular orientation.

Item Type: Article
Funders: Kementerian Pendidikan Malaysia (KPM) [TRGS/1/2016/UM/01/4/2]
Uncontrolled Keywords: FSI; Trabecular bone; Compressive loading; Numerical analysis; Bone marrow
Subjects: Q Science > QH Natural history > QH301 Biology
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Medicine > Orthopaedic Surgery Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Jun 2022 01:53
Last Modified: 13 Jun 2022 01:53
URI: http://eprints.um.edu.my/id/eprint/34247

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