Impact of graphene derivatives as artificial extracellular matrices on mesenchymal stem cells

Ikram, Rabia and Shamsuddin, Shamsul Azlin Ahmad and Mohamed Jan, Badrul and Abdul Qadir, Muhammad and Kenanakis, George and Stylianakis, Minas M. and Anastasiadis, Spiros H. (2022) Impact of graphene derivatives as artificial extracellular matrices on mesenchymal stem cells. Molecules, 27 (2). ISSN 1420-3049, DOI

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Thanks to stem cells' capability to differentiate into multiple cell types, damaged human tissues and organs can be rapidly well-repaired. Therefore, their applicability in the emerging field of regenerative medicine can be further expanded, serving as a promising multifunctional tool for tissue engineering, treatments for various diseases, and other biomedical applications as well. However, the differentiation and survival of the stem cells into specific lineages is crucial to be exclusively controlled. In this frame, growth factors and chemical agents are utilized to stimulate and adjust proliferation and differentiation of the stem cells, although challenges related with degradation, side effects, and high cost should be overcome. Owing to their unique physicochemical and biological properties, graphene-based nanomaterials have been widely used as scaffolds to manipulate stem cell growth and differentiation potential. Herein, we provide the most recent research progress in mesenchymal stem cells (MSCs) growth, differentiation and function utilizing graphene derivatives as extracellular scaffolds. The interaction of graphene derivatives in human and rat MSCs has been also evaluated. Graphene-based nanomaterials are biocompatible, exhibiting a great potential applicability in stem-cell-mediated regenerative medicine as they may promote the behaviour control of the stem cells. Finally, the challenges, prospects and future trends in the field are discussed.

Item Type: Article
Funders: Universiti Malaya[IF062-2019], Universiti Malaya[FP050-2019A], Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation[T2EDK-02073]
Uncontrolled Keywords: Nanotechnology;Graphene oxide;Mesenchymal stem cells;Tissue engineering
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 04 Aug 2022 02:04
Last Modified: 04 Aug 2022 02:04

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