Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications

Mousavi, Seyyed Mojtaba and Behbudi, Gity and Gholami, Ahmad and Hashemi, Seyyed Alireza and Nejad, Zohre Mousavi and Bahrani, Sonia and Chiang, Wei-Hung and Wei, Lai Chin and Omidifar, Navid (2022) Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications. Biomaterials Research, 26 (1). ISSN 1226-4601, DOI

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Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures' crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.

Item Type: Article
Uncontrolled Keywords: Shape controlled zinc oxide nanostructures; Biomedical applications; Reactive oxidative stress; Macromolecules
Subjects: R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Aug 2022 00:52
Last Modified: 05 Aug 2022 00:52

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