Synthetic material for bone, periodontal, and dental tissue regeneration: Where Are we now, and where are we heading next?

Cheah, Chia Wei and Al-Namnam, Nisreen Mohammed and Lau, May Nak and Lim, Ghee Seong and Raman, Renukanth and Fairbairn, Peter and Ngeow, Wei Cheong (2021) Synthetic material for bone, periodontal, and dental tissue regeneration: Where Are we now, and where are we heading next? Materials, 14 (20). ISSN 1996-1944, DOI

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Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants beta-tricalcium phosphate (beta-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and beta-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and beta-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss(R) Regeneration, Silesden, UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

Item Type: Article
Uncontrolled Keywords: Bioglass; Bone substitute; Hydroxyapatite; Polymers; Synthetic
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Dentistry
Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery
Depositing User: Ms Zaharah Ramly
Date Deposited: 22 Aug 2022 00:13
Last Modified: 22 Aug 2022 00:13

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