Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?

Sarraf, Masoud and Nasiri-Tabrizi, Bahman and Yeong, Chai Hong and Hosseini, Hamid Reza Madaah and Saber-Samandari, Saeed and Basirun, Wan Jefrey and Tsuzuki, Takuya (2021) Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future? Ceramics International, 47 (3). pp. 2917-2948. ISSN 0272-8842, DOI https://doi.org/10.1016/j.ceramint.2020.09.177.

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Nanomedicine has seen a significant rise in the development of new research tools and clinically functional devices. In this regard, significant advances and new commercial applications are expected in the pharmaceutical and orthopedic industries. For advanced orthopedic implant technologies, appropriate nanoscale surface modifications are highly effective strategies and are widely studied in the literature for improving implant performance. It is well-established that implants with nanotubular surfaces show a drastic improvement in new bone creation and gene expression compared to implants without nanotopography. Nevertheless, the scientific and clinical understanding of mixed oxide nanotubes (MONs) and their potential applications, especially in biomedical applications are still in the early stages of development. This review aims to establish a credible platform for the current and future roles of MONs in nanomedicine, particularly in advanced orthopedic implants. We first introduce the concept of MONs and then discuss the preparation strategies. This is followed by a review of the recent advancement of MONs in biomedical applications, including mineralization abilities, biocompatibility, antibacterial activity, cell culture, and animal testing, as well as clinical possibilities. To conclude, we propose that the combination of nanotubular surface modification with incorporating sensor allows clinicians to precisely record patient data as a critical contributor to evidence-based medicine.

Item Type: Article
Funders: Universiti Malaya, Taylor's University, Sharif University of Technology
Uncontrolled Keywords: Mixed oxide nanotubes;Anodization;Electrochemistry; Nanomedicine;Bioassays
Subjects: Q Science > QD Chemistry
R Medicine
R Medicine > R Medicine (General) > Medical technology
T Technology > T Technology (General)
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 22 Aug 2022 01:45
Last Modified: 22 Aug 2022 01:45
URI: http://eprints.um.edu.my/id/eprint/28749

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