Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions

Bohan, Suhaila and Hamid, Marlina Tanty Ramli and Chan, Wai Yee and Vijayananthan, Anushya and Ramli, Norlisah and Kaur, Shaleen and Rahmat, Kartini (2021) Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions. Scientific Reports, 11 (1). ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-020-80124-4.

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This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum-assisted breast biopsy (DBT-VABB) of screening-detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions, and spiculated masses. In this institutionally approved study, a total of 170 (n=170) DBT-VABB were performed, 153 (90%) were for calcifications, 8 (4.7%) for spiculated mass, 5 (2.9%) for asymmetric density and 4 (2.4%) for architectural distortion. All these lesions were not detected on the corresponding ultrasound. Histopathology results revealed 140 (82.4%) benign, 9 (5.3%) borderline and 21 (12.4%) malignant lesions. The total upgrade rate at surgery was 40% for atypical ductal hyperplasia and 5.9% for ductal carcinoma in-situ. 3.6% discordant benign lesions showed no upgrade. DBT-VABB showed 100% specificity, 91.3% sensitivity and 100% positive predictive value (PPV) for detecting malignant lesions. The negative predictive value (NPV) was 80%. 2 (1.2%) patients had mild complications and 1 (0.6%) had severe pain. Our study showed that DBT-VABB was a safe and reliable method, with high sensitivity, specificity, PPV, and NPV in the diagnosis of non-palpable benign and malignant breast lesions. Our data also confirmed the accuracy of DBT-VABB in detecting malignant lesions and we suggest further surgical excision in borderline lesions for a more accurate diagnostic evaluation.

Item Type: Article
Uncontrolled Keywords: Breast-Precancerous conditions; Breast-Biopsy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 24 Mar 2022 03:31
Last Modified: 24 Mar 2022 04:18
URI: http://eprints.um.edu.my/id/eprint/28637

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