Bohan, Suhaila and Hamid, Marlina Tanty Ramli and Chan, Wai Yee and Vijayananthan, Anushya and Ramli, Norlisah and Kaur, Shaleen and Rahmat, Kartini (2021) Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions. Scientific Reports, 11 (1). ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-020-80124-4.
Full text not available from this repository.Abstract
This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum-assisted breast biopsy (DBT-VABB) of screening-detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions, and spiculated masses. In this institutionally approved study, a total of 170 (n=170) DBT-VABB were performed, 153 (90%) were for calcifications, 8 (4.7%) for spiculated mass, 5 (2.9%) for asymmetric density and 4 (2.4%) for architectural distortion. All these lesions were not detected on the corresponding ultrasound. Histopathology results revealed 140 (82.4%) benign, 9 (5.3%) borderline and 21 (12.4%) malignant lesions. The total upgrade rate at surgery was 40% for atypical ductal hyperplasia and 5.9% for ductal carcinoma in-situ. 3.6% discordant benign lesions showed no upgrade. DBT-VABB showed 100% specificity, 91.3% sensitivity and 100% positive predictive value (PPV) for detecting malignant lesions. The negative predictive value (NPV) was 80%. 2 (1.2%) patients had mild complications and 1 (0.6%) had severe pain. Our study showed that DBT-VABB was a safe and reliable method, with high sensitivity, specificity, PPV, and NPV in the diagnosis of non-palpable benign and malignant breast lesions. Our data also confirmed the accuracy of DBT-VABB in detecting malignant lesions and we suggest further surgical excision in borderline lesions for a more accurate diagnostic evaluation.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Breast-Precancerous conditions; Breast-Biopsy |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 24 Mar 2022 03:31 |
| Last Modified: | 24 Mar 2022 04:18 |
| URI: | http://eprints.um.edu.my/id/eprint/28637 |
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