Wearable patch delivery system for artificial pancreas health diagnostic-therapeutic application: A review

Ahmad, Nur Farrahain Nadia and Nik Ghazali, Nik Nazri and Wong, Yew Hoong (2021) Wearable patch delivery system for artificial pancreas health diagnostic-therapeutic application: A review. Biosensors and Bioelectronics, 189. ISSN 0956-5663, DOI https://doi.org/10.1016/j.bios.2021.113384.

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The advanced stimuli-responsive approaches for on-demand drug delivery systems have received tremendous attention as they have great potential to be integrated with sensing and multi-functional electronics on a flexible and stretchable single platform (all-in-one concept) in order to develop skin-integration with close-loop sensation for personalized diagnostic and therapeutic application. The wearable patch pumps have evolved from reservoirbased to matrix patch and drug-in-adhesive (single-layer or multi-layer) type. In this review, we presented the basic requirements of an artificial pancreas, surveyed the design and technologies used in commercial patch pumps available on the market and provided general information about the latest wearable patch pump. We summarized the various advanced delivery strategies with their mechanisms that have been developed to date and representative examples. Mechanical, electrical, light, thermal, acoustic and glucose-responsive approaches on patch form have been successfully utilized in the controllable transdermal drug delivery manner. We highlighted key challenges associated with wearable transdermal delivery systems, their research direction and future development trends.

Item Type: Article
Funders: 'Skim Latihan Akademik Muda' (SLAM) from Universiti Teknologi Malaysia (UTM), Impact-Oriented Interdisciplinary Research Grant Programme from Universiti Malaya (UM) (IIRG018B-2019)
Uncontrolled Keywords: Transdermal; Wearable patch; Drug delivery; Sensor; Patch pump; System
Subjects: Q Science > Q Science (General)
T Technology > T Technology (General)
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering > Department of Mechanical Engineering
Depositing User: Ms Zaharah Ramly
Date Deposited: 02 Jun 2022 02:36
Last Modified: 02 Jun 2022 02:36
URI: http://eprints.um.edu.my/id/eprint/27225

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