An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials

Razali, Masfueh and Ngeow, Wei Cheong and Omar, Ros Anita and Chai, Wen Lin (2021) An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials. Biomedicines, 9 (1). ISSN 2227-9059, DOI

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The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (p < 0.001), with YSZ exhibiting the lowest permeability among all materials. Photofunctionalization of implant abutment materials improved the biological seal of the surrounding soft tissue peri-implant interface.

Item Type: Article
Funders: Ministry of Higher Education High Impact Research Grant of Malaysia [UM.C/625/HIR/MOHE/DENT/05], Postgraduate Research Fund [PG355-2016A]
Uncontrolled Keywords: Biological seal; Ultraviolet; Zirconia abutments; Photofunctionalization; Implant-soft tissue interface; organotypic model; three-dimensional peri-implant mucosal model
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Apr 2022 03:02
Last Modified: 18 Apr 2022 03:02

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