Razali, Masfueh and Ngeow, Wei Cheong and Omar, Ros Anita and Chai, Wen Lin (2021) An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials. Biomedicines, 9 (1). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines9010078.
Full text not available from this repository.Abstract
The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (p < 0.001), with YSZ exhibiting the lowest permeability among all materials. Photofunctionalization of implant abutment materials improved the biological seal of the surrounding soft tissue peri-implant interface.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education High Impact Research Grant of Malaysia [UM.C/625/HIR/MOHE/DENT/05], Postgraduate Research Fund [PG355-2016A] |
| Uncontrolled Keywords: | Biological seal; Ultraviolet; Zirconia abutments; Photofunctionalization; Implant-soft tissue interface; organotypic model; three-dimensional peri-implant mucosal model |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Apr 2022 03:02 |
| Last Modified: | 18 Apr 2022 03:02 |
| URI: | http://eprints.um.edu.my/id/eprint/26791 |
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