Dengue protease inhibition activity of selected malaysian medicinal herbs

Salleh, H.M. and Chong, Soon Lim and Othman, Rozana and Hazni, Hazrina and Ahmad, Khadher and Mohd Yusoff, Mohd Yakub @ Zulkifli and Fauzi, Nurulwahidah and Wahab, Habibah A. and Liew, Sook Yee and Awang, Khalijah (2019) Dengue protease inhibition activity of selected malaysian medicinal herbs. Tropical Biomedicine, 36 (2). pp. 357-366. ISSN 0127-5720,

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Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved.

Item Type: Article
Funders: Ministry of Higher Education through the Trans Disciplinary Research Grant Scheme (TR001B-2014A), USIM C (PPP/ UCG-0116/FPQS/30/14316), Postgraduate Research Grant, PPP (PG101-2016A)
Uncontrolled Keywords: Culicidae; Aedes; C quinquefasciatus
Subjects: B Philosophy. Psychology. Religion > BP Islam. Bahaism. Theosophy, etc
Q Science > QD Chemistry
R Medicine
Divisions: Academy of Islamic Studies > Dept of Al-Quran & Al- Hadith
Centre for Foundation Studies in Science > Chemistry Division
Faculty of Medicine
Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 23 Jan 2020 08:13
Last Modified: 23 Jan 2020 08:13

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