Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

Khaligh, Nader Ghaffari and Mihankhah, Taraneh and Johan, Mohd Rafie and Juan, Joon Ching (2018) Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions. Monatshefte fur Chemie - Chemical Monthly, 149 (6). pp. 1083-1087. ISSN 0026-9247, DOI https://doi.org/10.1007/s00706-018-2174-2.

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Official URL: https://doi.org/10.1007/s00706-018-2174-2

Abstract

A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Cinnoline; Metal-free condition; One-pot synthesis; Saccharin; t-Butyl nitrite
Subjects: Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Jul 2019 08:14
Last Modified: 16 Jul 2019 08:14
URI: http://eprints.um.edu.my/id/eprint/21639

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