Engineering cell microenvironment using novel functional hydrogels

Zhang, X. and Liu, M. and Li, Y. and Dong, Y. and Pingguan-Murphy, Belinda and Lu, T.J. and Xu, F. (2015) Engineering cell microenvironment using novel functional hydrogels. European Polymer Journal, 72. pp. 590-601. ISSN 0014-3057, DOI

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Cell microenvironment plays critical roles in regulating cellular activities both spatially and temporally. Engineering cell microenvironment using hydrogels has attracted increasing attention given their native-mimicking properties. In particular, developing hydrogels with specific functions has recently emerged as novel biocomposites to enable the regulation of cell microenvironment from a variety of aspects such as the biological, mechanical and electrical microenvironment. In this review, the state-of-the-art methods for the preparation and application of several novel functional hydrogels are presented, including magnetic hydrogels, photoresponsive hydrogels, conductive hydrogels, thermoresponsive hydrogels, molecule-response hydrogels, as well as tough and stretchable hydrogels. In particular, the applications of these functional hydrogels for engineering cell microenvironment are also reviewed. Concluding remarks and perspectives for the future development of functional hydrogels are addressed.

Item Type: Article
Funders: National Natural Science Foundation of China (11372243 and 81401270), International Science & Technology Cooperation Program of China (2013DFG02930), Fundamental Research Funds for the Central Universities, China Young 1000-Talent Program, Ministry of Higher Education (MOHE), Government of Malaysia: high impact research (UM.C/HIR/MOHE/ENG/44)
Uncontrolled Keywords: Functional hydrogels; Cell microenvironment; Magnetic hydrogels; Conductive hydrogels; Photoresponsive hydrogels
Subjects: R Medicine
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Sep 2018 02:20
Last Modified: 10 Feb 2020 08:37

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