Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential

Malagobadan, S. and Nagoor, N.H. (2015) Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International, 2015. pp. 1-10. ISSN 2314-6133, DOI https://doi.org/10.1155/2015/716816.

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Official URL: http://dx.doi.org/10.1155/2015/716816


Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years. Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis. In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression. We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis. In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis.

Item Type: Article
Funders: High Impact Research Grant (HIR) (H-21001-F000036), Centre for Research in Biotechnology for Agriculture (CEBAR) RU Operation Grant (RU005C-2014)
Uncontrolled Keywords: Evaluation; MicroRNAs; Anoikis Pathways; Therapeutic Potential
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Jul 2017 03:48
Last Modified: 17 Jul 2017 03:48
URI: http://eprints.um.edu.my/id/eprint/17521

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