Malagobadan, S. and Nagoor, N.H. (2015) Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International, 2015. pp. 1-10. ISSN 2314-6133, DOI https://doi.org/10.1155/2015/716816.
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Abstract
Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years. Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis. In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression. We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis. In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis.
| Item Type: | Article |
|---|---|
| Funders: | High Impact Research Grant (HIR) (H-21001-F000036), Centre for Research in Biotechnology for Agriculture (CEBAR) RU Operation Grant (RU005C-2014) |
| Uncontrolled Keywords: | Evaluation; MicroRNAs; Anoikis Pathways; Therapeutic Potential |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Jul 2017 03:48 |
| Last Modified: | 17 Jul 2017 03:48 |
| URI: | http://eprints.um.edu.my/id/eprint/17521 |
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