Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics

Choi, J.R. and Tang, R. and Wang, S. and Wan Abas, Wan Abu Bakar and Pingguan-Murphy, Belinda and Xu, F. (2015) Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics. Biosensors and Bioelectronics, 74. pp. 427-439. ISSN 0956-5663, DOI

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Nucleic acid testing (NAT), as a molecular diagnostic technique, including nucleic acid extraction, amplification and detection, plays a fundamental role in medical diagnosis for timely medical treatment. However, current NAT technologies require relatively high-end instrumentation, skilled personnel, and are time-consuming. These drawbacks mean conventional NAT becomes impractical in many resource limited disease-endemic settings, leading to an urgent need to develop a fast and portable NAT diagnostic tool. Paper-based devices are typically robust, cost-effective and user-friendly, holding a great potential for NAT at the point of care. In view of the escalating demand for the low cost diagnostic devices, we highlight the beneficial use of paper as a platform for NAT, the current state of its development, and the existing challenges preventing its widespread use. We suggest a strategy involving integrating all three steps of NAT into one single paper-based sample-to-answer diagnostic device for rapid medical diagnostics in the near future. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Nucleic acid testing (NAT); Nucleic acid extraction; Amplification; Detection; Paper-based device; Point of care
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Depositing User: Mrs. Siti Mawarni Salim
Date Deposited: 29 Jul 2016 07:56
Last Modified: 10 Feb 2020 08:35

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