Choi, J.R. and Tang, R. and Wang, S. and Wan Abas, Wan Abu Bakar and Pingguan-Murphy, Belinda and Xu, F. (2015) Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics. Biosensors and Bioelectronics, 74. pp. 427-439. ISSN 0956-5663, DOI https://doi.org/10.1016/j.bios.2015.06.065.
Full text not available from this repository.Abstract
Nucleic acid testing (NAT), as a molecular diagnostic technique, including nucleic acid extraction, amplification and detection, plays a fundamental role in medical diagnosis for timely medical treatment. However, current NAT technologies require relatively high-end instrumentation, skilled personnel, and are time-consuming. These drawbacks mean conventional NAT becomes impractical in many resource limited disease-endemic settings, leading to an urgent need to develop a fast and portable NAT diagnostic tool. Paper-based devices are typically robust, cost-effective and user-friendly, holding a great potential for NAT at the point of care. In view of the escalating demand for the low cost diagnostic devices, we highlight the beneficial use of paper as a platform for NAT, the current state of its development, and the existing challenges preventing its widespread use. We suggest a strategy involving integrating all three steps of NAT into one single paper-based sample-to-answer diagnostic device for rapid medical diagnostics in the near future. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Nucleic acid testing (NAT); Nucleic acid extraction; Amplification; Detection; Paper-based device; Point of care |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Depositing User: | Mrs. Siti Mawarni Salim |
| Date Deposited: | 29 Jul 2016 07:56 |
| Last Modified: | 10 Feb 2020 08:35 |
| URI: | http://eprints.um.edu.my/id/eprint/16190 |
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