Pulmonary toxicity of instilled silver nanoparticles: Influence of size, coating and rat strain

Seiffert, J. and Hussain, F. and Wiegman, C. and Li, F. and Bey, L. and Baker, W. and Porter, A. and Ryan, M.P. and Chang, Y. and Gow, A. and Zhang, J.F. and Zhu, J. and Tetley, T.D. and Chung, K.F. (2015) Pulmonary toxicity of instilled silver nanoparticles: Influence of size, coating and rat strain. PLoS ONE, 10 (3). p. 17. ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0119726.

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Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP) respiratory toxicity that may also depend on the lung inflammatory state. We compared the effects of intratracheally-administered AgNPs (20nm and 110nm; polyvinylpyrrolidone (PVP) and citrate-capped; 0.1 mg/Kg) in Brown-Norway (BN) and Sprague-Dawley (SD) rats. In BN rats, there was both a neutrophilic and eosinophilic response, while in SD rats, there was a neutrophilic response at day 1, greatest for the 20nm citrate-capped AgNPs. Eosinophilic cationic protein was increased in bronchoalveolar lavage (BAL) in BN and SD rats on day 1. BAL protein and malondialdehyde levels were increased in BN rats at 1 and 7 days, and BAL KC, CCL11 and IL-13 levels at day 1, with increased expression of CCL11 in lung tissue. Pulmonary resistance increased and compliance decreased at day 1, with persistence at day 7. The 20nm, but not the 110 nm, AgNPs increased bronchial hyperresponsiveness on day 1, which continued at day 7 for the citrate-capped AgNPs only. The 20nm versus the 110 nm size were more proinflammatory in terms of neutrophil influx, but there was little difference between the citrate-capped versus the PVP-capped AgNPs. AgNPs can induce pulmonary eosinophilic and neutrophilic inflammation with bronchial hyperresponsiveness, features characteristic of asthma.

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Uncontrolled Keywords: Brown-norway rats, consumer spray products, ion release kinetics, intratracheal instillation, airway hyperresponsiveness, nano-silver, inhalation, inflammation, exposure, cells,
Subjects: T Technology > T Technology (General)
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Mr Jenal S
Date Deposited: 25 Jul 2015 02:12
Last Modified: 04 Jul 2017 07:44
URI: http://eprints.um.edu.my/id/eprint/13797

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