Rotavirus genotypes in Malaysia and universal rotavirus vaccination

Lee, Way Seah and Lim, B.T.Y. and Chai, P.F. and Kirkwood, C.D. and Lee, J.K.F. (2012) Rotavirus genotypes in Malaysia and universal rotavirus vaccination. Human Vaccines & Immunotherapeutics, 8 (10). pp. 1-6. ISSN 2164-5515,

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Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the eff ectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE, and published genotype-specifi c effi cacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected eff ectiveness was 75.7% to 88.1% for Rotateq® and 78.7% to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq® and 28 to 32 deaths annually forRotarix®. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia.

Item Type: Article
Uncontrolled Keywords: Group A rotavirus genotypes; universal vaccination; Malaysia
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine
Depositing User: Ms. Izzan Ramizah Idris
Date Deposited: 18 Jun 2014 01:01
Last Modified: 29 Nov 2019 07:04

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