Lee, Way Seah and Lim, B.T.Y. and Chai, P.F. and Kirkwood, C.D. and Lee, J.K.F. (2012) Rotavirus genotypes in Malaysia and universal rotavirus vaccination. Human Vaccines & Immunotherapeutics, 8 (10). pp. 1-6. ISSN 2164-5515,
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Abstract
Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the eff ectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE, and published genotype-specifi c effi cacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected eff ectiveness was 75.7% to 88.1% for Rotateq® and 78.7% to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq® and 28 to 32 deaths annually forRotarix®. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Group A rotavirus genotypes; universal vaccination; Malaysia |
| Subjects: | R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Izzan Ramizah Idris |
| Date Deposited: | 18 Jun 2014 01:01 |
| Last Modified: | 29 Nov 2019 07:04 |
| URI: | http://eprints.um.edu.my/id/eprint/10604 |
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