Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia

Kam, T.S. and Yap, W.S. and Gan, C.Y. and Low, Y.Y. and Choo, Y.M. and Etoh, T. and Hayashi, M. and Komiyama, K. (2011) Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia. Journal of Natural Products, 74. pp. 1309-1312. ISSN 0163-3864, DOI

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Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Alkaloids; Kopsia grandifolia; Venalstonine; Lapidilectine.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 01:53
Last Modified: 15 Oct 2014 01:53

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