Kam, T.S. and Yap, W.S. and Gan, C.Y. and Low, Y.Y. and Choo, Y.M. and Etoh, T. and Hayashi, M. and Komiyama, K. (2011) Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia. Journal of Natural Products, 74. pp. 1309-1312. ISSN 0163-3864, DOI https://doi.org/10.1021/np200008g.
![[img]](http://eprints.um.edu.my/style/images/fileicons/application_pdf.png) |
PDF
Grandilodines_A—C,_Biologically_Active_Indole_Alkaloids_from_Kopsia_grandifolia.pdf - Published Version Restricted to Repository staff only Download (1MB) | Request a copy |
Abstract
Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, University of Malaya |
| Uncontrolled Keywords: | Alkaloids; Kopsia grandifolia; Venalstonine; Lapidilectine. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Suhaila Syakila Alby |
| Date Deposited: | 15 Oct 2014 01:53 |
| Last Modified: | 15 Oct 2014 01:53 |
| URI: | http://eprints.um.edu.my/id/eprint/10390 |
Actions (login required)
 |
View Item |
