Poznanski, R.R. and Ng, L.S. and Woo, C.S. (2010) A method for estimating gap-junctional conductance between ca3 hippocampal pyramidal neurons. Journal of Integrative Neuroscience, 9 (01). pp. 49-64. ISSN 0219-6352,
Full text not available from this repository.Abstract
Coupling ratio analysis using dual intracellular recording combined with ultrastructural examination of particles in plaques corresponding to gap-junctional channels is a quantitative measure of electrotonic coupling. The difficulty in combining both electrophysiological and morphological methods in determining the gap-junctional conductance of electrical synapses is addressed through the use of a passive cable model of two electrotonically coupled CA3 hippocampal pyramidal cells. Cable estimates of the gap-junctional coupling conductance based on electrophysiological data are combined with freeze-fracture replicas of connexin channels (gap-junctions) to confirm strong coupling between the somata of CA3 pyramidal neurons, based on the assumption that the electrical synapse works as an ohmic resistor influenced by an ensemble of unitary resistances of gap-junctional channels.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Faculty of Computer Science & Information Technology Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Gap-junctions; CA3 hippocampal pyramidal cells; somatic coupling resistance; electrotonic synapse; cable model; connexin Cx36 |
| Subjects: | T Technology > T Technology (General) |
| Divisions: | Faculty of Computer Science & Information Technology > Department of Artificial Intelligence |
| Depositing User: | Miss Nur Jannatul Adnin Ahmad Shafawi |
| Date Deposited: | 05 Apr 2013 02:12 |
| Last Modified: | 05 Apr 2013 02:12 |
| URI: | http://eprints.um.edu.my/id/eprint/5413 |
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