Innovative metal-organic frameworks for targeted oral cancer therapy: A review

Mousavi, Seyyed Mojtaba and Hashemi, Seyyed Alireza and Fallahi Nezhad, Fatemeh and Binazadeh, Mojtaba and Dehdashtijahromi, Milad and Omidifar, Navid and Ghahramani, Yasamin and Lai, Chin Wei and Chiang, Wei-Hung and Gholami, Ahmad (2023) Innovative metal-organic frameworks for targeted oral cancer therapy: A review. Materials, 16 (13). ISSN 1996-1944, DOI https://doi.org/10.3390/ma16134685.

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Abstract

Metal-organic frameworks (MOFs) have proven to be very effective carriers for drug delivery in various biological applications. In recent years, the development of hybrid nanostructures has made significant progress, including developing an innovative MOF-loaded nanocomposite with a highly porous structure and low toxicity that can be used to fabricate core-shell nanocomposites by combining complementary materials. This review study discusses using MOF materials in cancer treatment, imaging, and antibacterial effects, focusing on oral cancer cells. For patients with oral cancer, we offer a regular program for accurately designing and producing various anticancer and antibacterial agents to achieve maximum effectiveness and the lowest side effects. Also, we want to ensure that the anticancer agent works optimally and has as few side effects as possible before it is tested in vitro and in vivo. It is also essential that new anticancer drugs for cancer treatment are tested for efficacy and safety before they go into further research.

Item Type: Article
Funders: Fundamental Research Grant Scheme [Grant No: FRGS/1/2020/TK0/UM/02/8 ; FP023-2020], Global Collaborative Programme-SATU Joint Research Scheme ST004-2021
Uncontrolled Keywords: Metal-organic frameworks (MOFs); Oral squamous cell carcinoma (OSCC); BioMOFs
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
T Technology > T Technology (General)
Divisions: Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 08 Nov 2025 10:47
Last Modified: 08 Nov 2025 10:47
URI: http://eprints.um.edu.my/id/eprint/49743

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