Lani, Rafidah and Thariq, Ilya Maisarah and Suhaimi, Nuramira Syazreen and Hassandarvish, Pouya and Abu Bakar, Sazaly (2024) From defense to offense: Modulating toll-like receptors to combat arbovirus infections. Human Vaccines & Immunotherapeutics, 20 (1). ISSN 2164-5515, DOI https://doi.org/10.1080/21645515.2024.2306675.
Full text not available from this repository.Abstract
Arboviruses are a significant threat to global public health, with outbreaks occurring worldwide. Toll-like receptors (TLRs) play a crucial role in the innate immune response against these viruses by recognizing pathogen-associated molecular patterns and initiating an inflammatory response. Significantly, TLRs commonly implicated in the immune response against viral infections include TLR2, TLR4, TLR6, TLR3, TLR7, and TLR8; limiting or allowing them to replicate and spread within the host. Modulating TLRs has emerged as a promising approach to combat arbovirus infections. This review summarizes recent advances in TLR modulation as a therapeutic target in arbovirus infections. Studies have shown that the activation of TLRs can enhance the immune response against arbovirus infections, leading to increased viral clearance and protection against disease. Conversely, inhibition of TLRs can reduce the excessive inflammation and tissue damage associated with arbovirus infection. Modulating TLRs represents a potential therapeutic strategy to combat arbovirus infections.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia for niche area research under the Higher Institution Centre of Excellence (HICoE) program [MO002-2019] |
| Uncontrolled Keywords: | Infectious disease; arboviruses; toll-like receptors; modulation; agonist; antagonist; adjuvant |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology > QR180 Immunology T Technology > T Technology (General) |
| Divisions: | Faculty of Medicine Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Jun 2024 02:23 |
| Last Modified: | 11 Jun 2024 02:23 |
| URI: | http://eprints.um.edu.my/id/eprint/44152 |
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