Sagadevan, Suresh and Schirhagl, Romana and Rahman, Md Zillur and Ismail, Muhamad Fareez Bin and Lett, J. Anita and Fatimah, Is and Kaus, Noor Haida Mohd and Oh, Won-Chun (2023) Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications. Journal of Drug Delivery Science and Technology, 82. ISSN 1773-2247, DOI https://doi.org/10.1016/j.jddst.2023.104313.
Full text not available from this repository.Abstract
Several polymer-based nanocomposites have been studied and used for tissue engineering applications in recent years. These biodegradable nanocomposites have proven advantageous for bone tissue cultivation and produc-tion. Materials such as polymers, metals, and ceramics are commonly used to fabricate biomaterials. Although some polymeric materials are biodegradable and bioactive in bone tissue engineering applications, they do not match the strength of the bone. On the other hand, metals come in various shapes and sizes, including screws, pins, plates, and stents. These metallic implants are mechanically strong and can temporarily support bones, joints, and teeth. They are neither absorbed/resorbed by the body nor transformed into bone. With metal im-plants, there is also a possibility of infection and secondary operations. In contrast, polymer nanocomposites have bioinertness, low chemical reactivity, biocompatibility, osseointegration, regeneration, and deposition of mineral components capability. They can mimic bones, joints, and teeth in orthopedic applications to repair and replace damaged or diseased tissues. This study reviews current research on bone regeneration technology and potential treatment options for bone tissue regeneration in specific bone abnormalities with nanocomposites. The incorporation of growth factors into nanocomposite scaffolds for osteogenesis and bone remodeling is also discussed.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [Grant No: MG020-2022] |
| Uncontrolled Keywords: | Nanotechnology; Polymers; Nanocomposites; Bone tissue engineering; Orthopedic |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) > Medical technology T Technology > T Technology (General) |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 10 Nov 2024 04:39 |
| Last Modified: | 10 Nov 2024 04:39 |
| URI: | http://eprints.um.edu.my/id/eprint/38469 |
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