Hedayatnasab, Ziba and Dabbagh, Ali and Abnisa, Faisal and Karimian, Hamed and Abu Kasim, Noor Hayaty and Daud, Wan Mohd Ashri Wan (2021) Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy. Chemical Papers, 75 (2). pp. 669-679. ISSN 2585-7290, DOI https://doi.org/10.1007/s11696-020-01265-4.
Full text not available from this repository.Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of two iron precursors, though applying less amount of these chemicals may minimize the toxicity risks for biomedical purposes. The aim of this study is to address this issue by considering the high oxidation vulnerability of ferrous ions to ferric ions to synthesize SPIONs via a single-iron precursor under four varied oxidative conditions. The obtained results implied that the properties of SPIONs can be modified by the variation in the oxidizing conditions. Thereby, the optimal sample was produced as the oxygen/nitrogen flow ratio adjusted to 50% in the synthesis environment. The induction heating efficiency of this optimal sample was investigated under the exposure of varied alternating magnetic field (AMF), which resulted in a remarkable specific absorption rate (SAR) of 168.96 W g(-1) while maintaining the temperature medium within the secure hyperthermia range. The cytotoxic effect of the optimal SPIONs sample against human liver carcinoma (HepG2) cells was determined using MTT assay, leading to a considerable decrement in the cell viability. The incorporation of SPIONs under the AMF exposure is, therefore, considered as an effectual mechanism to the tumor intervention. GRAPHICS] .
| Item Type: | Article |
|---|---|
| Funders: | UMRG project of the University of Malaya [RP042A-17AET] |
| Uncontrolled Keywords: | Superparamagnetic; Iron oxide nanoparticles; Oxidation; Specific absorption rate; In vitro magnetic hyperthermia; Cytotoxicity |
| Subjects: | T Technology > T Technology (General) T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering > Department of Chemical Engineering |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Aug 2022 04:30 |
| Last Modified: | 16 Aug 2022 04:30 |
| URI: | http://eprints.um.edu.my/id/eprint/28552 |
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