Lin, Yu Kiat and Leong, Hui Yi and Ling, Tau Chuan and Lin, Dong-Qiang and Yao, Shan-Jing (2021) Raman spectroscopy as process analytical tool in downstream processing of biotechnology. Chinese Journal of Chemical Engineering, 30. pp. 204-211. ISSN 1004-9541, DOI https://doi.org/10.1016/j.cjche.2020.12.008.
Full text not available from this repository.Abstract
Downstream processing or product recovery plays a vital role in the development of bioprocesses. To improve the bioprocess efficiency, some unconventional methods are much required. The continuous manufacturing in downstream processing makes the Process Analytical Technologies (PATs) as an important tool. Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design. Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements. Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form, non-destructive, non-invasive optical molecular spectroscopic imaging with computer-based analysis. Generally, its application is essential for the analysis and characterization of biological samples, and it is easy to operate with minimal sample. The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique. Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis. Thus, this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | National Natural Science Foundation of China (NSFC) (21878263), National Natural Science Foundation of China (NSFC) (22078286), Zhejiang University, Talent-Introduction Program of China |
| Uncontrolled Keywords: | Raman spectroscopy; Process analytical technology; Downstream bioprocessing; Biotechnology |
| Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 25 Jul 2022 01:54 |
| Last Modified: | 25 Jul 2022 01:54 |
| URI: | http://eprints.um.edu.my/id/eprint/28096 |
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