Teh, Cindy Shuan Ju and Lee, Yee Qing and Kong, Zhi Xian and Woon, Jia Jie and Niek, Wen Kiong and Lau, Min Yi and Nuryana, Idris and Sasheela, Sri La Sri Ponnampalavanar and Ho, Peng Foong and Por, Lip Yee (2021) Development of a web-based multidrug-resistant organisms (MDRO) monitoring and transmission tracking system on the basis of microbiology and molecular characteristics. Journal of Taibah University for Science, 15 (1). pp. 303-311. ISSN 1658-3655, DOI https://doi.org/10.1080/16583655.2021.1978807.
Full text not available from this repository.Abstract
Pulsed-field gel electrophoresis (PFGE) remains the tool for transmission and outbreak tracing. However, inter-laboratory comparison of PFGE could not be made due to the lack of a standard for interpretation and congruence profiles assignment. This study aims to overcome the shortcoming of PFGE profiling, as well as human performance in data analysis by developing a web-based tool for monitoring multidrug-resistant organisms (MDRO) and tracking the transmission based on PFGE. A web-based MDRO monitoring and transmission tracking system was developed based on three main subsystems. To build the database, banding patterns of PFGE were converted into string data using the box-based fragmentation method. The data could be visualized based on different categories and the transmission tracing could be achieved by the coexistence of the similar profile. This system could be used for monitoring the genotypic and phenotypic trends of MDRO and to trace potential outbreaks in hospitals.
| Item Type: | Article |
|---|---|
| Funders: | This work was supported by Universiti Malaya [Grant number: RK016-2019]. |
| Uncontrolled Keywords: | MDRO; Web database; Box-based fragmentation; PFGE; Surveillance; String data |
| Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology T Technology > T Technology (General) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 16 Feb 2022 06:52 |
| Last Modified: | 16 Feb 2022 06:52 |
| URI: | http://eprints.um.edu.my/id/eprint/26296 |
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