Muthiah, Bavanilatha and Lovina, - and Arthi, - and Muthukrishnan, Lakshmipathy and Lett, J. Anita and Sagadevan, Suresh and Kesavan, Sudha and Vennila, Selvaraj and Khan, M. Ajmal and Hegazy, H. H. and Ahmad, Naushad (2020) Eucalyptus concoction mediated synthesis of gold nanoparticles and its bioactive role xxplored via antimicrobial and cytotoxic studies. Journal of Nanoscience and Nanotechnology, 20 (10). pp. 6326-6333. ISSN 1533-4880, DOI https://doi.org/10.1166/jnn.2020.17897.
Full text not available from this repository.Abstract
Biosynthesis of nanoparticles has now become a novel trend in addressing some of the environmental issues by adopting eco-friendly approaches in manoeuvring nanoparticles for various applications. Plants and micro-organisms have been the potential sources of the biological mode of synthesizing nanoparticles as part of their bioremediation process. This principle has been harnessed for synthesizing nanoparticles either extra or intracellularly. In this line of phyto-mediated synthesis, eucalyptus buds have been used for synthesizing gold nanoparticles (Au NPs) under optimized laboratory conditions. The UV-visible spectrum of the Au NPs showed typical surface plasmon resonance at 550 nm (lambda(max)) with a crystalline phase measuring <100 nm in size and monodispersed as revealed from XRD, FESEM, and AFM analyses. The biological role of phytochemical concoction in reducing and stabilizing the Au NPs was clearly identified from FT-IR studies. The antimicrobial effect of the Au NPs against clinically important pathogens viz. Staphylococcus sp., Pseudomonas sp., Bacillus sp. and E. coli determined using the disk diffusion method showed no significant antibacterial effect at all concentrations. Cytotoxicity studies were carried using Vero and HEp-2 cell lines and the 50% inhibition concentration (IC50) was determined to be 1.25 mg and 0.625 mg/mL respectively. Au NPs with potential antimicrobial and anti-proliferative effects could found profound implications in the field of nanomedicine once the toxicity in vivo has been investigated.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Gold nanoparticles; Antimicrobial activity; Antitumor effects; Cytotoxic effect; Eucalyptus |
| Subjects: | T Technology > T Technology (General) T Technology > TS Manufactures |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 30 Nov 2023 03:58 |
| Last Modified: | 30 Nov 2023 03:58 |
| URI: | http://eprints.um.edu.my/id/eprint/36376 |
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