Benchtop technologies for circulating tumor cells separation based on biophysical properties

Low, W.S. and Wan Abas, Wan Abu Bakar (2015) Benchtop technologies for circulating tumor cells separation based on biophysical properties. BioMed Research International. p. 22. ISSN 2314-6133

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Circulating tumor cells (CTCs) are tumor cells that have detached from primary tumor site and are transported via the circulation system. The importance of CTCs as prognostic biomarker is leveraged when multiple studies found that patient with cutoff of 5 CTCs per 7.5 mL blood has poor survival rate. Despite its clinical relevance, the isolation and characterization of CTCs can be quite challenging due to their large morphological variability and the rare presence of CTCs within the blood. Numerous methods have been employed and discussed in the literature for CTCs separation. In this paper, we will focus on label free CTCs isolation methods, in which the biophysical and biomechanical properties of cells (e.g., size, deformability, and electricity) are exploited for CTCs detection. To assess the present state of various isolation methods, key performance metrics such as capture efficiency, cell viability, and throughput will be reported. Finally, we discuss the challenges and future perspectives of CTC isolation technologies.

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Uncontrolled Keywords: Breast-cancer cells, atomic-force microscopy, red-blood-cells, on-a-chip, prostate-cancer, bone-marrow, particle separation, microfluidic device, efficient isolation, flow-fractionation,
Subjects: T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Mr Jenal S
Date Deposited: 14 Apr 2016 06:57
Last Modified: 25 Oct 2018 08:42

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