Development of a passive liquid valve (PLV) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform

Al-Faqheri, W. and Ibrahim, Fatimah and Thio, T.H.G. and Bahari, N. and Arof, Hamzah and Rothan, Hussin A. and Yusof, Rohana and Madou, M. (2015) Development of a passive liquid valve (PLV) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform. Sensors, 15 (3). pp. 4658-4676. ISSN 1424-8220, DOI https://doi.org/10.3390/s150304658.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/25723143

Abstract

In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger.

Item Type: Article
Funders: University of Malaya High Impact Research Grant from Ministry of Higher Education Malaysia (MOHE) UM-MOHE UM.C/625/1/HIR/MOHE/05, Fundamental Research Grant Scheme FRGS: FP042-2013B , University of Malaya Research Grant UMRG: RG009A-13AET , Yayasan Sultan Iskandar Johor Foundation , National Institute of Health 1 R01 AI089541-01
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Uncontrolled Keywords: Centrifugal platform, microfluidic CD, passive liquid valve, pressure, equilibrium, S-PLV, D-PLV, DESIGN, CD,
Subjects: T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Mr Jenal S
Date Deposited: 04 Apr 2016 01:12
Last Modified: 11 Oct 2018 04:14
URI: http://eprints.um.edu.my/id/eprint/15726

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