Alhalawani, A.M.F. and Rodriguez, O. and Curran, D.J. and Co, R. and Kieran, S. and Arshad, S. and Keenan, T.J. and Wren, A.W. and Crasto, G. and Peel, S.A.F. and Towler, M.R. (2015) A glass polyalkenoate cement carrier for bone morphogenetic proteins. Journal of Materials Science-Materials in Medicine, 26 (3). p. 151. ISSN 0957-4530, DOI https://doi.org/10.1007/s10856-015-5494-3.
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Abstract
This work considers a glass polyalkenoate cement (GPC)-based carrier for the effective delivery of bone morphogenetic proteins (BMPs) at an implantation site. A 0.12 CaO-0.04 SrO-0.36 ZnO-0.48 SiO2 based glass and poly(acrylic acid) (PAA, Mw 213,000) were employed for the fabrication of the GPC. The media used for the water source in the GPC reaction was altered to produce a series of GPCs. The GPC liquid media was either 100 distilled water with additions of albumin at 0, 2, 5 and 8 wt of the glass content, 100 formulation buffer (IFB), and 100 BMP (150 mu g rhBMP-2/ml IFB). Rheological properties, compressive strength, ion release profiles and BMP release were evaluated. Working times (T-w) of the formulated GPCs significantly increased with the addition of 2 albumin and remained constant with further increases in albumin content or IFB solutions. Setting time (T-s) experienced an increase with 2 and 5 albumin content, but a decrease with 8 albumin. Changing the liquid source to IFB containing 5 albumin had no significant effect on T-s compared to the 8 albumin-containing BT101. Replacing the albumin with IFB/BMP-2 did not significantly affect T-w. However, T-s increased for the BT101BMP-2 containing GPCs, compared to all other samples. The compressive strength evaluated 1 day post cement mixing was not affected significantly by the incorporation of BMPs, but the ion release did increase from the cements, particularly for Zn and Sr. The GPCs released BMP after the first day, which decreased in content during the following 6 days. This study has proven that BMPs can be immobilized into GPCs and may result in novel materials for clinical applications.
| Item Type: | Article |
|---|---|
| Funders: | Natural Sciences and Engineering Research Council of Canada (NSERC) Engage Program 449,981-13 |
| Additional Information: | ISI Document Delivery No.: CE1PA Times Cited: 0 Cited Reference Count: 46 Cited References: Alhalawani Adel M F, 2013, J Funct Biomater, V4, P329, DOI 10.3390/jfb4040329 Autefage H, 2009, J BIOMED MATER RES B, V91B, P706, DOI 10.1002/jbm.b.31447 Bellido T, 2003, J BIOL CHEM, V278, P50259, DOI 10.1074/jbc.M307444200 Bessa PC, 2008, J TISSUE ENG REGEN M, V2, P81, DOI 10.1002/term.74 Bessa PC, 2008, J TISSUE ENG REGEN M, V2, P1, DOI 10.1002/term.63 Bessho K, 2002, J BIOMED MATER RES, V61, P61, DOI 10.1002/jbm.10169 Boontheekul T, 2003, CURR OPIN BIOTECH, V14, P559, DOI 10.1016/j.copbio.2003.08.004 BOYAN BD, 1992, CLIN ORTHOP RELAT R, P286 Boyd D, 2008, J MATER SCI-MATER M, V19, P1745, DOI 10.1007/s10856-007-3363-4 Boyd D, 2008, J MATER SCI-MATER M, V19, P953, DOI 10.1007/s10856-006-0060-7 Brown KV, 2011, TISSUE ENG PT A, V17, P1735, DOI 10.1089/ten.TEA.2010.0446, 10.1089/ten.tea.2010.0446 CARTER DR, 1976, SCIENCE, V194, P1174, DOI 10.1126/science.996549 Chen S, 2013, SCI TECHNOL ADV MAT, V14, DOI 10.1088/1468-6996/14/1/015005 CRISP S, 1974, J DENT RES, V53, P1414, DOI 10.1177/00220345740530062001 Fu RW, 2013, ANN INTERN MED, V158, P890, DOI 10.7326/0003-4819-158-12-201306180-00006 Furlan L, 1996, POLYMER, V37, P843, DOI 10.1016/0032-3861(96)87263-6 Johnson MR, 2009, ACTA BIOMATER, V5, P23, DOI 10.1016/j.actbio.2008.09.001 Khairoun I, 1998, J MATER SCI-MATER M, V9, P425, DOI 10.1023/A:1008811215655 Kleeff J, 1999, GASTROENTEROLOGY, V116, P1202, DOI 10.1016/S0016-5085(99)70024-7 Lane JM, 1999, CLIN ORTHOP RELAT R, P216 LANGER R, 1976, NATURE, V263, P797, DOI 10.1038/263797a0 Lee KB, 2012, J ORTHOP RES, V30, P1985, DOI 10.1002/jor.22160 Luginbuehl V, 2004, EUR J PHARM BIOPHARM, V58, P197, DOI 10.1016/j.ejpb.2004.03.004 Mayer H, 1996, CALCIFIED TISSUE INT, V58, P249 Mehta M, 2012, ADV DRUG DELIVER REV, V64, P1257, DOI 10.1016/j.addr.2012.05.006 Mori M, 2000, J BIOMED MATER RES, V50, P191, DOI 10.1002/(SICI)1097-4636(200005)50:2<191::AID-JBM14>3.0.CO;2-0 Niedhart C, 2003, J BIOMED MATER RES A, V65A, P17, DOI 10.1002/jbm.a.10362 Patel ZS, 2008, ACTA BIOMATER, V4, P1126, DOI 10.1016/j.actbio.2008.04.002 Pneumaticos SG, 2010, J CELL MOL MED, V14, P2561, DOI 10.1111/j.1582-4934.2010.01062.x Rai B, 2005, BIOMATERIALS, V26, P3739, DOI 10.1016/j.biomaterials.2004.09.052 Raida M, 2005, J CANCER RES CLIN, V131, P741, DOI 10.1007/s00432-005-0024-1 Reddi AH, 2005, CYTOKINE GROWTH F R, V16, P249, DOI 10.1016/j.cytogfr.2005.04.003 Reddi AH, 1998, NAT BIOTECHNOL, V16, P247, DOI 10.1038/nbt0398-247 Redweik S, 2013, ELECTROPHORESIS, V34, P1812, DOI 10.1002/elps.201300050 Seeherman H, 2005, CYTOKINE GROWTH F R, V16, P329, DOI 10.1016/j.cytogfr.2005.05.001 Seiya J, 2002, J ORTHOP SCI, V7, P490 Shields LBE, 2006, SPINE, V31, P542, DOI 10.1097/01.brs.0000201424.27509.72 URIST MR, 1983, P SOC EXP BIOL MED, V173, P194 van de Weert M, 2000, PHARM RES, V17, P1159 WILSON AD, 1970, J DENT RES, V49, P7, DOI 10.1177/00220345700490013301 Wilson AD, 2005, ACID BASE CEMENTS TH Wren A, 2008, J MATER SCI-MATER M, V19, P1737, DOI 10.1007/s10856-007-3287-z Wren AW, 2010, J MATER SCI, V45, P3554, DOI 10.1007/s10853-010-4398-3 Wren AW, 2013, J MATER SCI-MATER M, V24, P1167, DOI 10.1007/s10856-013-4880-y Xie GP, 2010, J MATER SCI-MATER M, V21, P1875, DOI 10.1007/s10856-010-4038-0 Yuan HP, 2001, J MATER SCI-MATER M, V12, P761, DOI 10.1023/A:1013957431372 Alhalawani, Adel M. F. Rodriguez, Omar Curran, Declan J. Co, Russell Kieran, Sean Arshad, Saad Keenan, Timothy J. Wren, Anthony W. Crasto, Gazelle Peel, Sean A. F. Towler, Mark R. Natural Sciences and Engineering Research Council of Canada (NSERC) Engage Program 449,981-13 The authors thank the Natural Sciences and Engineering Research Council of Canada (NSERC) Engage Program (Grant # 449,981-13) for facilitating this research. 0 SPRINGER DORDRECHT J MATER SCI-MATER M |
| Uncontrolled Keywords: | Sustained-release, delivery-systems, spine fusion, in-vitro, bmp-2, regeneration, biomaterial, adsorption, induction, rhbmp-2, |
| Subjects: | T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Engineering |
| Depositing User: | Mr Jenal S |
| Date Deposited: | 17 Sep 2015 04:08 |
| Last Modified: | 17 Sep 2015 04:08 |
| URI: | http://eprints.um.edu.my/id/eprint/14003 |
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