An age-adjusted seroprevalence study of Toxoplasma antibody in a Malaysian ophthalmology unit

Singh, S. and Khang, T.F. and Andiappan, H. and Nissapatorn, V. and Subrayan, V. (2012) An age-adjusted seroprevalence study of Toxoplasma antibody in a Malaysian ophthalmology unit. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (5). pp. 322-326. ISSN 0035-9203,

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Toxoplasma gondii is a public health risk in developing countries, especially those located in the tropics. Widespread infection may inflict a substantial burden on state resources, as patients can develop severe neurological defects and ocular diseases that result in lifelong loss of economic independence. We tested sera for IgG antibody from 493 eye patients in Malaysia. Overall age-adjusted seroprevalence was estimated to be 25 (95 CI: 21%, 29%). We found approximately equal age-adjusted seroprevalence in Chinese (31%; 95% CI: 25%, 38%) and Malays (29%; 95% CI: 21%, 36%), followed by Indians (19%; 95% CI: 13%, 25%). A logistic regression of the odds for T. gondii seroprevalence against age, gender, ethnicity and the occurrence of six types of ocular diseases showed that only age and ethnicity were significant predictors. The odds for T. gondii seroprevalence were 2.7 (95% CI for OR: 1.9, 4.0) times higher for a patient twice as old as the other, with ethnicity held constant. In Malays, we estimated the odds for T. gondii seroprevalence to be 2.9 (95% CI for OR: 1.8, 4.5) times higher compared to non-Malays, with age held constant. Previous studies of T. gondii seroprevalence in Malaysia did not explicitly adjust for age, rendering comparisons difficult. Our study highlights the need to adopt a more rigorous epidemiological approach in monitoring T. gondii seroprevalence in Malaysia. (C) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: ISI Document Delivery No.: 937WA Times Cited: 0 Cited Reference Count: 18 Singh, Sujaya Khang, Tsung Fei Andiappan, Hemah Nissapatorn, Veeranoot Subrayan, Visvaraja University of Malaya FS366/2008C This study was supported by a grant, FS366/2008C, from the University of Malaya. Elsevier science inc New york
Uncontrolled Keywords: Toxoplasma gondii Seroprevalence IgG antibody Ocular diseases Age-related macular degeneration risk-factors population infection gondii prevalence pregnancy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 03 Oct 2013 01:21
Last Modified: 03 Oct 2013 01:21

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