Beta-sitosterol induces apoptosis in MCF-7 cells

Chai, J.W. and Kuppusamy, U.R. and Kanthimathi, M.S. (2008) Beta-sitosterol induces apoptosis in MCF-7 cells. Malaysian Journal of Biochemistry and Molecular Biology, 16 (2). pp. 28-30. DOI

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Cyrtandra cupulata Ridl. (Gesneriaceae) is local medicinal plant, also known as �Bebangun� or �Kabut� by the East Malaysian Ibans. It is indicated for post partum malaise and known to be an abortifacient, among other uses. β-Sitosterol is a known phytoestrogen with many reported bioactivities including anticancer. This study examined the effect of β-sitosterol isolated from C. cupulata through bioactivity-guided purification monitored by the growth inhibitory effect on MCF-7, an estrogen receptorpositive breast cancer cell line. Our results demonstrated that β-sitosterol dose-dependently inhibited the growth of MCF-7 cells. Treated cells showed a 1.53-fold increase of DEVDase activity, indicating elevated caspase activity. Thus, the growth inhibitory effect of β-sitosterol isolated from C. cupulata appeared to be mediated by caspase-induced apoptosis.

Item Type: Article
Uncontrolled Keywords: beta-sitosterol; apoptosis; MCF-7; Cyrtandra cupulata
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2013 04:14
Last Modified: 11 Dec 2013 03:54

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