Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

Huang, N.M. and Haw, C.Y. and Mohamed, F. and Chia, C.H. and Radiman, S. and Zakaria, S. and Lim, H.N. (2010) Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. Ceramics International, 36 (4). pp. 1417-1422. ISSN 02728842, DOI https://doi.org/10.1016/j.ceramint.2010.02.005.

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Magnetite (Fe 3O 4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl 2·4H 2O and FeCl 3 with NaOH as reducing agent to initiate the precipitation of Fe 3O 4, followed by hydrothermal treatment to produce nano-sized Fe 3O 4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe 3O 4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe 3O 4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe 3O 4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe 3O 4 nanoparticles. The superparamagnetic behaviour of the produced Fe 3O 4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe 3O 4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging. © 2010 Elsevier Ltd and Techna Group S.r.l.

Item Type: Article
Uncontrolled Keywords: B. Surfaces C. Magnetic properties E. Biomedical applications Hydrothermal Biomedical applications Contrast-enhanced Fourier transform infrared spectrums Hydrothermal process Hydrothermal treatments Inverse spinel structures Magnetic resonance imaging contrast agents Magnetite nanoparticles MR imaging MRI contrast agents Nano-sized Phantom studies Potential applications Room temperature Superparamagnetics TEM Vibrating sample magnetometer X-ray diffraction techniques Chitin Chitosan Fourier transform infrared spectroscopy Hydrothermal synthesis Magnetic properties Magnetic resonance Magnetic resonance imaging Magnetite Nanoparticles Oxide minerals Scanning electron microscopy Superparamagnetism Transmission electron microscopy X ray diffraction Nanomagnetics
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Divisions: Faculty of Science > Department of Physics
Depositing User: miss munirah saadom
Date Deposited: 01 Apr 2013 02:23
Last Modified: 01 Apr 2013 02:23
URI: http://eprints.um.edu.my/id/eprint/5306

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