Mycobacterial antibody levels and immune restoration disease in HIV patients treated in South East Asia

Sumatoh, H.R. and Oliver, B.G. and Kumar, M. and Elliott, J.H. and Vonthanak, S. and Vun, M.C. and Singh, S. and Agarwal, U. and Kumar, A. and Tan, H.Y. and Kamarulzaman, A. and Yunihastuti, E. and Saraswati, H. and Price, P. (2011) Mycobacterial antibody levels and immune restoration disease in HIV patients treated in South East Asia. Biomarkers in Medicine, 5 (6). pp. 847-853. ISSN 1752-0363,

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Aim: Immune restoration disease (IRD) associated with Mycobacterium tuberculosis parallels the reconstitution of a pathogen-specific Th1 response. However, it is not clear whether humoral responses to M. tuberculosis antigens also rise, or whether antibody levels predict IRD. Here, humoral immunity to M. tuberculosis antigens was investigated in four Asian cohorts. Methods: Plasma samples were obtained from longitudinal prospective studies of HIV patients beginning antiretroviral therapy (ART) in New Delhi (India), Kuala Lumpur (Malaysia), Jakarta (Indonesia) and Phnom Penh (Cambodia). IgG antibodies to purified protein derivative, lipoarabinomannan and 38-kDa antigens of M. tuberculosis were quantitated using in-house ELISAs. IRD was defined as exacerbated symptoms of tuberculosis in patients on anti-tuberculosis therapy or a novel presentation of tuberculosis on ART. Results: Pre-ART IgG levels to purified protein derivative, lipoarabinomannan and 38-kDa antigen were similar in the IRD and control groups from each site. Compared with non-IRD controls, a higher proportion of IRD patients had elevated IgG levels to lipoarabinomannan (defined as a greater than twofold increase) over 12 weeks of ART. However, this trend was not significant for the other antigens and longitudinal analyses did not reveal clear rises in antibody levels at the time of IRD. Conclusion: Levels of antibody to mycobacterial antigens do not predict IRD, but levels of antibody reactive with lipoarabinomannan rise during an IRD in some patients.

Item Type: Article
Additional Information: Sumatoh, Hermi R. Oliver, Benjamin G. Kumar, Manoj Elliott, Julian H. Vonthanak, Saphonn Vun, Mean Chhi Singh, Sarman Agarwal, Upasna Kumar, Amitabh Tan, Hong Yien Kamarulzaman, Adeeba Yunihastuti, Evy Saraswati, Heni Price, Patricia
Uncontrolled Keywords: Antibody; antiretroviral therapy; HIV; immune restoration disease; Mycobacterium tuberculosis
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 04 Feb 2013 01:41
Last Modified: 01 Oct 2018 03:45

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