Ruthenium(II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy

Ng, Xiao Ying and Fong, Kar Wai and Kiew, Lik Voon and Chung, Pooi Yin and Liew, Yun Khoon and Delsuc, Nicolas and Zulkefeli, Mohd and Low, May Lee (2024) Ruthenium(II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy. Journal of Inorganic Biochemistry, 250. ISSN 0162-0134, DOI

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Photodynamic therapy (PDT) has recently emerged as a potential valuable alternative to treat microbial infections. In PDT, singlet oxygen is generated in the presence of photosensitisers and oxygen under light irradiation of a specific wavelength, causing cytotoxic damage to bacteria. This review highlights different generations of photosensitisers and the common characteristics of ideal photosensitisers. It also focuses on the emergence of ruthenium and more specifically on Ru(II) polypyridyl complexes as metal-based photosensitisers used in antimicrobial photodynamic therapy (aPDT). Their photochemical and photophysical properties as well as structures are discussed while relating them to their phototoxicity. The use of Ru(II) complexes with recent advancements such as nanoformulations, combinatory therapy and photothermal therapy to improve on previous shortcomings of the complexes are outlined. Future perspectives of these complexes used in two-photon PDT, photoacoustic imaging and sonotherapy are also discussed. This review covers the literature published from 2017 to 2023. © 2023 Elsevier Inc.

Item Type: Article
Funders: IRDI, Institute for Research, Development and Innovation, Ministry of Higher Education, Malaysia, International Medical University
Uncontrolled Keywords: Antibacterial; Metals in medicine; Photodynamic therapy; Photosensitisers; Ruthenium(II) polypyridyl complexes
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 Apr 2024 07:05
Last Modified: 15 Apr 2024 07:05

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