Antibody levels of COVID-19 vaccine: A comparison between healthy subjects and psychiatric patients on antidepressants

Thin, Ling Shiau and Guan, Ng Chong and Jeswant Singh, Jesjeet Singh Gill and Mohd Yussof, Nur Hamimmi and Hou, Lee Si and Ping, Ang Kuan and Abousheishaa, Aya Ahmed (2022) Antibody levels of COVID-19 vaccine: A comparison between healthy subjects and psychiatric patients on antidepressants. Current Topics in Pharmacology, 26. 39 – 47. ISSN 0972-4559,

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This study compares the serological antibody level post-COVID-19 vaccine among healthy subjects and psychiatric patients on antidepressant therapy. It also examines the difference in antidepressants’ side effects experienced by psychiatric patients following the completion of two vaccine doses. A comparative posttest quasi-experimental study was conducted among healthy subjects and psychiatric patients on antidepressant medication in a teaching hospital in Malaysia. Elecsys Anti-SARS-CoV-2 assay was used to detect the antibody titre between weeks 4 and 12 post vaccination. The antidepressant side-effect checklist (ASEC) was used to monitor the occurrence of antidepressant-related side effects pre-and post-vaccination. 24 psychiatric patients and 26 healthy subjects were included. There was no significant difference in the antibody level between the patients (median = 1509 u/ml) and the healthy subjects (median = 995 u/ml). There was no significant worsening in the antidepressant-related side effects. The antibody level post-COVID-19 vaccine did not differ significantly between patients on antidepressant therapy and healthy subjects. Additionally, there was no change in the antidepressant side effects experienced by the patients following the completion of the vaccine. © 2022, Research Trends (P) LTD.. All rights reserved.

Item Type: Article
Funders: None
Additional Information: Cited by: 0
Uncontrolled Keywords: Agomelatine; Antidepressant agent; Escitalopram; Mirtazapine; Receptor binding domain; SARS-CoV-2 vaccine; Sertraline; Tozinameran; Unclassified drug; Virus spike protein; Vortioxetine; Adult; Antibody blood level; Antibody response; Antibody titer; Antidepressant activity; Article; Blurred vision; Clinical article; Comparative study; Constipation; Controlled study; Coronavirus disease 2019; Decreased appetite; Diarrhea; Disorientation; Educational status; Employment status; Female; Headache; Heart palpitation; Human; Immune response; Insomnia; Male; Mental disease; Nausea and vomiting; Quasi experimental study; Seroprevalence; Sexual dysfunction; Somnolence; Sweating; Tremor; Vaccination; Xerostomia
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine > Psychological Medicine Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Nov 2023 08:56
Last Modified: 03 Dec 2023 01:41

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