COVID-19: How effective are the repurposed drugs and novel agents in treating the infection?

Suet-May, Chow and Sin-Yee, Kuok and Jia-Qing, Lee and Pey-Wen, Goh and Ranjit Singh, Harleen Kaur A.P. and Zhi-Zheng, Timothy Tan and Foo, Jhi-Biau and Hamzah, Sharina and Sellappans, Renukha and Yow, Hui-Yin (2022) COVID-19: How effective are the repurposed drugs and novel agents in treating the infection? Sudan Journal of Medical Sciences, 17 (4). 498 – 538. ISSN 1858-5051, DOI

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Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment. This review paper discusses the effectiveness of repurposed drugs used to treat COVID-19 and potential novel therapies for COVID-19. Among the various repurposed drugs, remdesivir is the only agent approved by the Food and Drug Administration (FDA) to treat COVID-19. On the other hand, several drugs have been listed in the Emergency Use Authorization (EUA) by the FDA to treat COVID-19, including casirivimab and imdevimab, baricitinib (in combination with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors. In addition, in vitro and clinical studies have suggested cepharanthine, sotrovimab, and XAV-19 as potential treatments to manage COVID-19. Due to inadequate understanding of COVID-19 and the rapid mutation of SARS-CoV-2, COVID-19 remains a threat to global public health, with vaccination considered the most effective method to decrease COVID-19 transmission currently. Nevertheless, with the intense efforts of clinical researchers globally, more promising treatments for COVID-19 will be established in the future. © 2022, Knowledge E. All rights reserved.

Item Type: Article
Funders: Ministry of Higher Education, Malaysia, FRGS/1/2019/SKK09/TAYLOR/03/1
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: Antiviral agents; COVID-19; Drug repurposing; SARS-CoV-2; Treatment
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmaceutical Life Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 29 Nov 2023 03:54
Last Modified: 29 Nov 2023 03:54

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