Atypical presentation of langerhans cell histiocytosis of temporal bone in a toddler

Lee, Eng Siang and Saniasiaya, Jeyasakthy and Kulasegarah, Jeyanthi and Kok, Wai Leong and Chew, Seow Fun (2022) Atypical presentation of langerhans cell histiocytosis of temporal bone in a toddler. Indian Journal of Otology, 28 (3). pp. 242-245. ISSN 0971-7749, DOI

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Ever since Langerhans cell histiocytosis (LCH) was first described in 1865, mystery revolving around its cause and pathogenesis remains, although most agree that LCH is either a reactive or neoplastic process. We aim to highlight the importance of careful investigations of common presentation, which may lead to the diagnosis and treatment in a toddler. We report a case of LCH of the temporal bone with an atypical presentation in a toddler, which led to delayed diagnosis. The patient presented with a vague preauricular swelling and aural polyp. Imaging and histopathological examination of the biopsy revealed temporal bone LCH, and the child was referred to the pediatric oncology unit and successfully treated. This case clearly demonstrates the highly diversified clinical manifestation of LCH and the high level of suspicion required to diagnose it. We describe the challenge faced in managing this rare entity. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Item Type: Article
Funders: None
Uncontrolled Keywords: Antibiotic Agent; Chlordane; Mercaptopurine; Prednisone; T6 Antigen; Vinblastine; Abdomen; Anamnesis; Article; Auditory Canal; Axillary Lymph Node; Biopsy; Blood Analysis; Bone Erosion; Case Report; Cell Infiltration; Cervical Lymph Node; Cervical Lymphadenopathy; Chemotherapy; Chromatin; Clinical Article; Clinical Examination; Clinical Feature; Clinical Protocol; Computer Assisted Tomography; Cytoplasm; Delayed Diagnosis; Ear Tumor; Eardrum; Eosinophil; External Auditory Canal; External Otitis; Follow Up; General Anesthesia; Granulation Tissue; Histopathology; Human; Human Cell; Human Tissue; Infant; Iron Deficiency Anemia; Langerhans Cell; Langerhans Cell Histiocytosis; Lung Nodule; Male; Mastoid; Multidisciplinary Team; Multiple Cycle Treatment; Neck; Neutrophil; Nuclear Magnetic Resonance Imaging; Otoscopy; Patient Referral; Pelvis; Pelvis Lymph Node; Polyp; Repeat Procedure; Soft Tissue; Swelling; Temporal Bone; Temporal Lobe; Thorax; Tissue Injury; Treatment Planning; Treatment Response; Tumor Volume; Zygoma
Subjects: R Medicine > RF Otorhinolaryngology
Divisions: Faculty of Medicine > Otorhinolaryngology Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Dec 2023 07:20
Last Modified: 28 Dec 2023 07:20

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